Formulation: A crystalline solid
Formal Name: (αR)-methyl-1H-imidazole-5-ethanamine, dihydrochloride
Purity: ≥95%
Formula Markup: C6H11N3 • 2HCl
Formula Weight: 198,1
Shelf life (days): 1460
CAS Number: 75614-89-0
Notes: R-(−)-α-Methylhistamine is a histamine H3 receptor agonist with diverse biological activities.{43474} It inhibits the release of histamine induced by antidromic electrical stimulation of the sciatic nerve in rats when administered at doses ranging from 0.25 to 2 mg/kg, an effect that can be reversed by the selective histamine H3 receptor antagonist thioperamide (Item No. 10011127). R-(−)-α-Methylhistamine (0.5-50 nmol) inhibits gastric acid secretion in rats when administered intracerebroventricularly but not intravenously.{43475} It reduces isolation-induced vocalizations and aggressive behavior in a resident-intruder test in guinea pig pups and mice, respectively.{43476} R-(−)-α-Methylhistamine (30 mg/kg) decreases freezing time in a conditioned fear stress test in rats. It also acts synergistically with fentanyl to reduce nociception and plasma extravasation in a mouse model of chronic inflammation induced by complete Freund's adjuvant.{43477}
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