Formulation: A solid
Formal Name: 2-[3-[bis[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-1-phenylpropyl]-4-methyl-phenol, 2,3-dihydroxybutanedioate
Purity: ≥99% deuterated forms (d1-d14)
Formula Markup: C22H17D14NO • C4H6O6
Formula Weight: 489,7
Shelf life (days): 1460
Notes: rac-Tolterodine-d14 is intended for use as an internal standard for the quantification of tolterodine (Item No. 15027) by GC- or LC-MS. Tolterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1-5 receptors, respectively).{22772} It reduces intracellular calcium mobilization induced by carbachol (carbamoylcholine; Item No. 14486) in bladder smooth muscle cells and submandibular gland cells isolated from cynomolgus monkeys (Kis = 3.16 and 2 nM, respectively).{39587} Tolterodine inhibits volume-induced bladder contractions and oxotremorine-induced salivation in rats (ID50s = 0.025 and 0.12 mg/kg, respectively).{39586} Formulations containing tolterodine have been used in the treatment of overactive bladder.
English
Deutsch
