Formulation: A solid
Formal Name: 4-hydroxy-α-[[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]methyl-d2]-benzenemethan-d-ol, monohydrochloride
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C18H20D3NO3 • HCl
Formula Weight: 340,9
Shelf life (days): 1460
CAS Number: 1219794-72-5
Notes: Ractopamine-d3 is intended for use as an internal standard for the quantification of ractopamine (Item No. 27613) by GC- or LC-MS. Ractopamine is a trace amine-associated receptor 1 (TAAR1) agonist.{64567} It increases chloride conductance in X. laevis oocytes expressing the human cystic fibrosis transmembrane conductance regulator (CFTR) and mouse TAAR1 (EC50 = 16 µM), an effect that can be blocked by the TAAR1 antagonist EPPTB (Item No. 34330). It selectively induces chloride conductance in TAAR1- and CFTR-expressing oocytes over those expressing the human β2-adrenergic receptor (β2-AR) and CFTR at 36 µM. However, it is also considered a β2-AR agonist that binds to β2-ARs (Ki = 0.18 µM for the recombinant human receptor expressed in Sf9 cells) and induces relaxation of isolated guinea pig trachea with an EC50 value of 9.1 nM.{64568} Formulations containing ractopamine have been used as food additives in livestock to increase weight gain and leanness and improve feed efficiency.
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