RCGD 423, CAS 108237-91-8

Formulation: A solid

Formal Name: N-(4-bromophenyl)-4-phenyl-2-thiazolamine

Purity: ≥98%

Formula Markup: C15H11BrN2S

Formula Weight: 331,2

Shelf life (days): 1460

CAS Number: 108237-91-8

Notes: RCGD 423 is a modulator of gp130.{58005} It increases levels of phosphorylated STAT3 and Myc in isolated pig articular chondrocytes (EC50s = 4.5-7.2 µM), effects that can be reversed by the gp130 inhibitor SC144 (Item No. 29714). RCGD 423 reduces cellular apoptosis and hypertrophy induced by bone morphogenic protein 4 (BMP4) in isolated mouse total limb cells and isolated human healthy and osteoarthritic articular chondrocytes. In vivo, RCGD 423 (4 µg/joint) reduces cartilage loss in a rat model of osteochondral injury.

• SKU: CAY31420-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 31420-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK