Formulation: A solid
Formal Name: 2-(ethoxy-1,1,2,2,2-d5)-4-[2-[[(1S)-3-methyl-1-[2-(1-piperidinyl)phenyl]butyl]amino]-2-oxoethyl]-benzoic acid
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C27H31D5N2O4
Formula Weight: 457,6
Shelf life (days): 1460
CAS Number: 1217709-85-7
Notes: Repaglinide-d5 is intended for use as an internal standard for the quantification of repaglinide (Item No. 19387) by GC- or LC-MS. Repaglinide is a metaglitinide antidiabetic agent that blocks ATP-dependent potassium (Kir6) channels in pancreatic β-cells (Kd = 0.42 nM for the sulphonylurea receptor SUR1 when co-expressed with Kir6.2).{32299} In vivo, repaglinide lowers blood glucose in fasted rats and dogs (ED50s = 10 and 28.3 μg/kg, respectively).{32300} Formulations containing repaglinide have been used to control blood sugar levels in patients with type 2 diabetes.
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