Formulation: A crystalline solid
Formal Name: (αR)-α-methyl-4-(2-methylpropyl)-N-(methylsulfonyl)-benzeneacetamide
Purity: ≥95%
Formula Markup: C14H21NO3S
Formula Weight: 283,4
Shelf life (days): 730
CAS Number: 266359-83-5
Notes: Reparixin is an allosteric antagonist of chemokine (C-X-C motif) receptor 1 (CXCR1) and CXCR2 (IC50s = 1 and 100 nM, respectively).{28557} In vivo, reparixin (3, 15, and 30 mg/kg) reduces ischemia and reperfusion-induced hepatic polymorphonuclear leukocyte (PMN) recruitment, hepatic myeloperoxidase (MPO) levels, and serum alanine transaminase (ALT) levels in a rat model of hepatic ischemia. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 5 mg/kg.{28553} Reparixin, in combination with docetaxel (Item No. 11637), reduces tumor volume and the number of intratumor cancer stem cells in a SUM159 triple-negative breast cancer (TNBC) mouse xenograft model.{28554}
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