Rilmenidine, CAS 54187-04-1

Formulation: A crystalline solid

Formal Name: N-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine

Purity: ≥95%

Formula Markup: C10H16N2O

Formula Weight: 180,2

Shelf life (days): 1460

CAS Number: 54187-04-1

Notes: Rilmenidine is an antihypertensive agent.{61133} It binds to imidazole receptors in bovine rostral ventrolateral medulla homogenates (Ki = 6.1 nM), as well as α2-adrenergic receptors in bovine prefrontal cortex homogenates (Ki = 87 nM). Rilmenidine induces hypotension and bradycardia in anesthetized rats (ED50s = 0.25 and 0.35 mg/kg, respectively). It also reduces mean arterial pressure and renal sympathetic nerve activity in a rabbit model of renal hypertension induced by a renal artery clip when administered at a dose of 2.5 mg/kg.{61134} Rilmenidine (1 µM) increases levels of LC3-II, a marker of autophagy, in PC12 cells.{30143} Formulations containing rilmenidine have been used in the treatment of hypertension.

• SKU: CAY32879-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 32879-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK