Formulation: A solid
Formal Name: 6-(trifluoromethoxy)-2-benzothiazolamine
Purity: ≥98%
Formula Markup: C8H5F3N2OS
Formula Weight: 234,2
Shelf life (days): 1460
CAS Number: 1744-22-5
Notes: Riluzole is an inhibitor of calcium channels.{51334} It is selective for the voltage-gated calcium channels Cav2.2 and Cav2.1 over Cav1.2 at 30 µM. Riluzole (10 µM) inhibits increases in intracellular calcium levels induced by NMDA (Item No. 14581), L-glutamic acid (Item No. 30377), or veratridine in primary rat cerebellar granule cells.{51335} It reduces glutamate, but not aspartate, release from the left caudate nucleus in cats when used at a concentration of 10 µM.{51336} Riluzole reduces slow wave activity and increases high frequency neuronal activity induced by carotid artery occlusion (CAO) in gerbils in a dose-dependent manner and decreases the CAO-induced infarcted cortex volume in rats when administered at a dose of 8 mg/kg.{51337} Dietary administration of riluzole (44 mg/kg per day) increases survival time and the total distance ran in an SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS).{51333} Formulations containing riluzole have been used in the treatment of ALS.
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