Formulation: A crystalline solid
Formal Name: 6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
Purity: ≥95%
Formula Markup: C27H25F2N3OS
Formula Weight: 477,6
Shelf life (days): 730
CAS Number: 87051-43-2
Notes: Ritanserin is a selective antagonist of the serotonin (5-HT) receptor subtype, 5-HT2A.{39295} In a radioligand binding assay, ritanserin exhibits high selectivity for 5-HT2A over 5-HT1 receptors (IC50s = 0.9 nM and >1000 nM, respectively).{39296} It also demonstrates relatively low affinity for histamine H1, dopamine D2, α1-adrenergic, and α2-adrenergic receptors (39-, 77-, 107-, and 166-fold lower relative to 5-HT2A, respectively). Ritanserin (2.5 mg/kg) is long-acting, occupying >70% of 5-HT2A sites up to 48 hours following subcutaneous administration to rats and guinea pigs. In vivo, ritanserin (10 mg/kg) blocks 5-hydroxy tryptophan-induced head twitches in rats.{39297}
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