Formulation: A solid
Formal Name: 2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-bis(methyl-d3)ethan-1-amine, monobenzoate
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C15H13D6N5 • C7H6O2
Formula Weight: 397,5
Shelf life (days): 1460
CAS Number: 1216984-85-8
Notes: Rizatriptan-d6 is intended for use as an internal standard for the quantification of rizatriptan (Item No. 16475) by GC- or LC-MS. Rizatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (Kis = 4.3 and 10.1 nM, respectively).{34530} It is selective for 5-HT1B and 5-HT1D receptors over 5-HT1A receptors (Ki = 140 nM). Rizatriptan induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 90 nM).{34529} In vivo, rizatriptan (50 and 75 mg/kg) reduces head grooming, the number of oculotemporal strokes, eye blinking, and one-eye closures in a Cacna1a mutant transgenic mouse model of migraine.{57443} Formulations containing rizatriptan have been used in the treatment of migraine.
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