Formulation: A solid
Formal Name: 2-(3-pyridinyl)-1-azabicyclo[2.2.2]octane, dihydrochloride
Purity: ≥98%
Formula Markup: C12H16N2 • 2HCl
Formula Weight: 261,2
Shelf life (days): 1460
CAS Number: 1021418-53-0
Notes: RJR 2429 is a nicotinic acetylcholine receptor (AChR) agonist.{49443} It is selective for α4β2 or α7 subunit-containing nicotinic AChRs (Kis = 0.7 and 10.9 nM in isolated rat cortex and isolated rat hippocampus, respectively) over α1βɣδ subunit-containing nicotinic AChRs (EC50 = 1,000 nM in PC12 cells). RJR 2429 induces dopamine release from isolated rat striatal synaptosomes (EC50 = 2.4 nM) and increases nicotine-induced elevations in epinephrine and norepinephrine levels in isolated rat adrenal gland when used at a concentration of 100 µM.{49444},{49446} It inhibits nicotine-induced ion flux in isolated rat thalamic synaptosomes (IC50 = 154 nM).{49444}
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