RN-1747, CAS 1024448-59-6

Formulation: A solid

Formal Name: 1-[(4-chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-piperazine

Purity: ≥98%

Formula Markup: C17H18ClN3O4S

Formula Weight: 395,9

Shelf life (days): 1460

CAS Number: 1024448-59-6

Notes: RN-1747 is an agonist of transient receptor potential vanilloid 4 (TRPV4).{41579} It selectively induces calcium influx in HEK293 cells expressing human, rat, or mouse TRPV4 (EC50s = 0.77, 4.1, and 4 µM, respectively) over HEK293 cells expressing human TRPV1, TRPV3, or transient receptor potential melastatin 8 (TRPM8; EC50s = >100, >30, and >30 µM, respectively). RN-1747 (10 µM) induces inward current in Xenopus oocytes expressing human TRPV4. Topical, but not intravenous, administration of RN-1747 induces hypothermia in rats.{68536}

• SKU: CAY37573-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37573-25
• Package Unit: 25 mg
• Quantity Unit: STK