Ro 08-2750, CAS 37854-59-4

Formulation: A solid

Formal Name: 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-benzo[g]pteridine-8-carboxaldehyde

Purity: ≥95%

Formula Markup: C13H10N4O3

Formula Weight: 270,2

Shelf life (days): 1460

CAS Number: 37854-59-4

Notes: Ro 08-2750 is a p75 neurotrophin receptor (p75NTR) ligand that completely inhibits nerve growth factor (NGF) binding to p75NTR in PC12 cells when used at a concentration of 100 μM.{47722} It also binds to NGF dimers (Kd = ~1 μM) to induce a conformational change that prevents NGF binding to p75NTR or tropomyosin-related kinase A (TrkA). Ro 08-2750 inhibits NGF-induced death of SK-N-MC cells and inhibits autophosphorylation of TrkA in PC12 cells. It reverses NGF-induced decreases in β-catenin mRNA expression in, and migration of, SKOV3 and OVCAR-3 ovarian cancer cells.{47723}

• SKU: CAY28772-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28772-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK