Formulation: A solid
Formal Name: N-(1-oxobutyl)-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-N2-methyl-glycinamide, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C39H52N12O6 • XCF3COOH
Formula Weight: 784,9
Shelf life (days): 1460
CAS Number: 1373926-49-8
Notes: RO27-3225 is a peptide agonist of melanocortin receptor 4 (MC4R).{67879} It selectively induces cAMP production in cells expressing human MC4R (EC50 = 0.3 nM) over cells expressing MC1R, MC3R, or MC5R (EC50s = 1.1, 97.9, and 139.4 nM, respectively). In vivo, RO27-3225 (3, 5, and 10 nmol/animal) reduces food intake in rats, as well as in obese db/db mice when administered at a dose of 200 µg/animal. RO27-3225 also reduces brain edema, blood-brain barrier (BBB) permeability, and hippocampal Il-1β and Tnf-α levels in a rat model of intra-abdominal hypertension induced by hemorrhagic shock and resuscitation.{67880}
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