Formulation: A solid
Formal Name: 4-(2-(propyl(propyl-d7)amino)ethyl)indolin-2-one, monohydrochloride
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C16H17D7N2O • HCl
Formula Weight: 303,9
Shelf life (days): 1460
CAS Number: 1261396-31-9
Notes: Ropinirole-d7 is intended for use as an internal standard for the quantification of ropinirole (Item No. 23871) by GC- or LC-MS. Ropinirole is a dopamine D2 receptor agonist that induces [35S]GTPγS binding in CHO cells expressing the human receptor (EC50 = 304 nM).{58103} It is selective for dopamine D2 over D1 receptors (Kis = 29 and >100,000 nM, respectively), as well as a panel of adrenergic, serotonin (5-HT), benzodiazepine, and GABA receptors (IC50s = >9,000 nM for all).{38497} Ropinirole reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg. It also induces contralateral asymmetry in 6-OHDA-lesioned mice. Ropinirole (0.01-1 mg/kg) reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of Parkinson's disease induced by MPTP. Formulations containing ropinirole have been used in the treatment of Parkinson's disease motor dysfunction.
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