Formulation: A solid
Formal Name: 2-hydroxy-N-[3-[3-(1-piperidinyl-2,2,3,3,4,4,5,5,6,6-d10-methyl)phenoxy]propyl]-acetamide, ethanedioate (2:1)
Purity: ≥99% deuterated forms (d1-d10)
Formula Markup: C17H16D10N2O3 • 1/2C2H2O4
Formula Weight: 361,5
Shelf life (days): 1460
CAS Number: 2832423-41-1
Notes: Roxatidine-d10 is intended for use as an internal standard for the quantification of roxatidine by GC- or LC-MS. Roxatidine is a histamine H2 receptor antagonist and major active metabolite of roxatidine acetate (Item No. 21248).{62168} Roxatidine reduces histamine-induced adenylate cyclase production in guinea pig parietal cells (IC50 = 0.8 µM). It inhibits histamine-induced hydrogen ion accumulation in the same cells (pA2 = 7.03). Roxatidine (200 mg/kg) reduces small intestinal lesion area in a rat model of gastric mucosal injury induced by indomethacin (Item No. 70270).{62169}
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