Formulation: A solid
Formal Name: 5-chloro-N-[2-[2-(cyclopropylmethoxy)phenoxy]ethyl]-α,α-dimethyl-1H-indole-3-ethanamine, monohydrochloride
Purity: ≥98%
Formula Markup: C24H29ClN2O2 • HCl
Formula Weight: 449,4
Shelf life (days): 1460
CAS Number: 169505-93-5
Notes: RS 17053 is an α1A-adrenergic receptor (α1A-AR) antagonist.{18268} It selectively binds to the α1A-AR (Ki = 2.5 nM) over α1B- and α1D-ARs (Kis = 50 and 79 nM, respectively). RS 17053 inhibits norepinephrine-induced contractions in isolated rat kidney and mesenteric arteries (pA2s = 9.8 and 9.9, respectively), tissues that endogenously express high levels of α1A-AR, and, to a lesser extent, in isolated rat aortic rings, which highly express α1D-ARs, and human lower urinary tract tissue (pA2s = 7.7 and 7.3, respectively).{62039} It also inhibits phenylephrine-induced increases in mean arterial pressure (MAP) in normotensive and spontaneously hypertensive rats (ED50s = 528 and 533 µg/kg, respectively).{62040}
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