Formulation: A crystalline solid
Formal Name: 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole, butanedioic acid (2:1)
Purity: ≥95%
Formula Markup: C14H16N2O • 1/2C4H6O4
Formula Weight: 287,3
Shelf life (days): 1460
CAS Number: 66611-27-6
Notes: RU-24969 is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B.{54787} It binds to 5-HT1A and 5-HT1B receptors (IC50s = 9.5 and 6.6 nM, respectively) and is selective for these receptors over 5-HT2 receptors in cell-free assays (IC50 = 5,120 nM). RU-24969 inhibits tritium efflux induced by the 5-HT antagonist methiothepin (Item No. 23138) in tritium-preloaded rat frontal cortex slices (pA2 = 6.27). In vivo, RU-24969 (3 mg/kg) potentiates cocaine-induced increases in nucleus accumbens dopamine levels, as well as the reinforcing effects of cocaine self-administration, in rats.{54788}
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