Formulation: A solid
Formal Name: 4-fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]-benzamide
Purity: ≥98%
Formula Markup: C24H26FN3O2
Formula Weight: 407,5
Shelf life (days): 1460
CAS Number: 135722-25-7
Notes: S 14506 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A.{52916,52917,52918,52919} It selectively binds 5-HT1A over 5-HT1B, 5-HT1C, 5-HT2, and 5-HT3 receptors (Kis = 0.98, 281.8, 31.6, 229, and >1,000 nM, respectively) but also binds the dopamine D2 receptor (Ki = 4.57 nM) in radioligand binding assays.{52916,52917} S 14506 stimulates GTPase activity in HEK293 cell membranes expressing 5-HT1A-Gαi1 or 5-HT1A-Gαo1 fusion proteins in a concentration-dependent manner.{52918} It reduces immobility time in the forced swim test in rats with a minimum effective dose (MED) of 0.01 mg/kg.{52919} S 14506 (0.0025-0.63 mg/kg) increases punished responding in a pigeon conflict procedure, indicating anxiolytic-like activity.{52916}
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