Formulation: A solid
Formal Name: α-amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, monohydrochloride
Purity: ≥95%
Formula Markup: C7H8FN3O4 • HCl
Formula Weight: 253,6
Shelf life (days): 1460
CAS Number: 1321546-70-6
Notes: (S)-(−)-5-Fluorowillardiine is an agonist of the ionotropic glutamate receptors GluA1 and GluA2.{66599} It selectively activates GluA1 and GluA2 over GluA3 and GluA4 in voltage-clamp assays using X. laevis oocytes expressing the flip isoforms of the rat receptors (EC50s = 0.382, 0.463, 20.9, and 11.9 µM, respectively). (S)-(−)-5-Fluorowillardiine induces evoked population spikes in isolated rat CA1 hippocampal slices in an in vitro model of seizure-like activity (EC50 = 0.03-0.08 µM).{66600} It induces cytotoxicity in primary mouse cortical neurons in a concentration-dependent manner, an effect that can be reversed by the GluA5 antagonist LY293558 or GluK2 antagonist NS-102.{66601}
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