Formulation: A solid
Formal Name: (2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol, monohydrochloride
Purity: ≥98%
Formula Markup: C13H18ClNO2 • HCl
Formula Weight: 292,2
Shelf life (days): 1460
CAS Number: 106083-71-0
Notes: S,S-hydroxy Bupropion is an active metabolite of the antidepressant bupropion.{57923,57924} It is formed from bupropion by the cytochrome P450 (CYP) isoform CYP2B6.{57925} S,S-hydroxy Bupropion inhibits dopamine and norepinephrine but not serotonin (5-HT) reuptake in HEK293 cells expressing the human transporters (IC50s = 0.63, 0.241, and >100 µM, respectively).{57923} It is also an antagonist of α3β4-, α4β2-, α4β4-, and α1β1 subunit-containing nicotinic acetylcholine receptors (nAChRs; IC50s = 11, 3.3, 30, and 28 µM, respectively). S,S-hydroxy Bupropion inhibits nicotine-induced analgesia in the tail-flick and hot plate tests, hyperlocomotion, and hypothermia in mice (ED50s = 0.2, 1, 0.9, and 1.5 mg/kg, respectively). It substitutes for (+)-amphetamine in rats in a two-lever drug discrimination test (ED50 = 4.4 mg/kg).{57924}
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