Formulation: A solid
Formal Name: S-sulfo-L-cysteine
Purity: ≥90%
Formula Markup: C3H7NO5S2
Formula Weight: 201,2
Shelf life (days): 1460
CAS Number: 1637-71-4
Notes: S-Sulfocysteine is an NMDA receptor agonist.{64749} It is selective for the NMDA receptor over the AMPA receptor in radioligand binding assays (EC50s = 8.2 and 59 µM, respectively). S-Sulfocysteine (200 µM) is cytotoxic to primary mouse neuronal cells.{64750} It induces calcium influx and activates calpain-dependent degradation of the post-synaptic scaffolding protein gephyrin when used at a concentration of 100 µM. S-Sulfocysteine (2 mM) increases swimming and seizure-like movements, indicating neurodegeneration, in zebrafish larvae when administered three days post-fertilization.{64748} Urinary and plasma levels of S-sulfocysteine are increased in patients with molybdenum cofactor deficiency (MoCD), an inborn error of metabolism characterized by neurodegeneration and early childhood death.{64750}
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