S7 (trifluoroacetate salt)

Formulation: A solid

Formal Name: L-leucyl-L-seryl-L-leucyl-L-threonyl-L-arginyl-L-leucine, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C37H70N10O10 • XCF3COOH

Formula Weight: 815

Shelf life (days): 1460

Notes: S7 is a peptide antagonist of the IL-6 receptor.{69504,69505} It inhibits IL-6 binding to the IL-6 receptor in a concentration-dependent manner.{69504} S7 (50 µM) inhibits IL-6-induced increases in VEGF levels in C-33 A cervical cancer cells and RPMI-8226 B cell lymphocytes. It reduces tumor volume in an IL-6-overexpressing C-33 A cervical cancer mouse xenograft model when administered at a dose of 50 mg/kg every two days. When coupled to cysteine and the surface of lipid nanoparticles (LNPs) encapsulating doxorubicin, S7 increases LNP glioma targeting and increases survival in a U251 glioblastoma mouse xenograft model. {69505}

• SKU: CAY37467-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37467-1
• Package Unit: 1 mg
• Quantity Unit: STK