Formulation: A solid
Formal Name: (3β,4α,16α)-16,23,28-trihydroxyoleana-11,13(18)-dien-3-yl 6-deoxy-3-O-β-D-glucopyranosyl-β-D-galactopyranoside
Purity: ≥95%
Formula Markup: C42H68O13
Formula Weight: 781
Shelf life (days): 1460
CAS Number: 58316-41-9
Notes: Saikosaponin B2 is a triterpenoid saponin that has been found in B. chinensis and has diverse biological activities.{68164,68814,62389} It is an antagonist of transient receptor potential ankyrin 1 (TRPA1) and inhibits calcium flux induced by polygodial (Item No. 14979) or allyl isothiocyanate in HEK293 cells expressing human TRPA1 when used at concentrations ranging from 0.5 to 1.5 µM.{68164} Saikosaponin B2 inhibits hepatitis C virus (HCV) viral entry into, but not replication in, Huh7.5 cells (EC50 = 16.13 µM) with a 50% cytotoxic concentration (CC50) value of 740.4 µM.{68814} It protects SH-SY5Y cells from hydrogen peroxide-induced cell death when used at a concentration of 50 µg/ml.{62389}
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