Formulation: A solid
Formal Name: α1-[[[1,1-di(methyl-d3)ethyl-2,2,2-d3]amino]methyl]-4-hydroxy-1,3-benzenedimethanol
Purity: ≥99% deuterated forms (d1-d9)
Formula Markup: C13H12D9NO3
Formula Weight: 248,4
Shelf life (days): 1460
CAS Number: 1173021-73-2
Notes: Salbutamol-d9 is intended for use as an internal standard for the quantification of salbutamol (Item Nos. 21003 / 23991) by GC- or LC-MS. Salbutamol is an agonist of the β2-adrenergic receptor (β2-AR; Kd = 759 nM in a radioligand binding assay using CHO cells expressing the human receptor).{25151} It is selective for β2-ARs over β1- and β3-ARs (Kds = 46.8 and 21.9 µM, respectively). Salbutamol (25-50 μg/kg, i.v.) reduces acetylcholine-induced bronchospasm in anesthetized guinea pigs.{40769} It also reduces response of bronchial muscle to efferent vagal stimulation in anesthetized cats and dogs when administered at doses ranging from 1 to 2.5 and 10 to 20 µg/kg, respectively. Nebulized salbutamol reduces transpulmonary pressure in recurrent airway obstruction-affected horses (EC50 = 39.7 µg).{40770} Formulations containing salbutamol have been used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
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