Formulation: A solid
Formal Name: 6-hydroxy-α3-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethan-α1,α1,α3-d3-ol, 1-hydroxy-2-naphthalenecarboxylic acid
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C25H34D3NO4 • C11H8O3
Formula Weight: 606,8
Shelf life (days): 1460
Notes: Salmeterol-d3 is intended for use as an internal standard for the quantification of salmeterol (Item No. 16009) by GC- or LC-MS. Salmeterol is a long-acting β2-adrenergic receptor agonist (β2-AR; EC50s = 0.79, 63.1, and 9.4 nM for β2-, β1-, and β3-ARs, respectively).{25442} It inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50 = 2.51 nM) and histamine-induced bronchoconstriction in guinea pigs via aerosol administration of doses ranging from 0.12 to 12 mM.{25442,42567} Salmeterol binds to an exosite domain of β2-adrenergic receptors, producing a slow onset of action and prolonged activation.{25994} Formulations containing salmeterol have been used in the treatment of asthma, including exercise-induced asthma, and chronic obstructive pulmonary disease.
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