SAR441255 (sodium salt)

Formulation: A solid

Purity: ≥95%

Formula Markup: C225H355N57O63 • XNa

Formula Weight: 4866,6

Shelf life (days): 1460

Notes: SAR441255 is a peptide triple agonist of the glucagon-like peptide 1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR).{67841} It induces cAMP accumulation in HEK293 cells expressing human GLP-1R, GIPR, or GCGR (EC50s = 1.03, 0.73, and 1.01 pM, respectively). SAR441255 (1-30 µg/kg) reduces body weight in a mouse model of high-fat diet-induced obesity. It also reduces body weight and blood hemoglobin A1c (HbA1c) levels in high-fat diet-induced obese diabetic cynomolgus monkeys when administered at a dose of 11 µg/kg.

• SKU: CAY41175-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41175-1
• Package Unit: 1 mg
• Quantity Unit: STK