Formulation: A solid
Formal Name: (S)-2-((S)-1-(L-arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylsulfonyl)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)(methyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide
Purity: ≥95%
Formula Markup: C64H100N18O15S • XCF3COOH
Formula Weight: 1393,7
Shelf life (days): 1460
Notes: [Sar9, Met(O2)11]-Substance P (Sar-SP) is a peptide agonist of the neurokinin-1 (NK1) receptor.{52563} It is selective for NK1 over NK2 and NK3 receptors. Sar-SP induces inositol phosphate formation in U373MG glioblastoma cells with an EC50 value of 3.8 nM, an effect that can be blocked by the NK1 receptor antagonist SR 140333.{52564} It induces contractions in isolated human bronchi when used at concentrations of 3, 100, and 1,000 nM.{52565} Sar-SP (10, 25, 65, and 100 pmol/animal, i.c.v.) increases mean arterial pressure and heart rate in conscious rats.{52566}
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