SB-200646 (hydrochloride), CAS 143797-62-0

Formulation: A solid

Formal Name: N-(1-methyl-1H-indol-5-yl)-N′-3-pyridinyl-urea, monohydrochloride

Purity: ≥98%

Formula Markup: C15H14N4O • HCl

Formula Weight: 302,8

Shelf life (days): 1460

CAS Number: 143797-62-0

Notes: SB-200646 is a dual antagonist of the serotonin (5-HT) receptor subtypes 5-HT2C (Ki = 125 nM in isolated rat cortex) and 5-HT2B (pA2 = 7.5 in rat stomach fundus preparations).{54226} It is selective for 5-HT2C and 5-HT2B over 5-HT1A, 5-HT2A, 5-HT1D, 5-HT3, benzodiazepine, GABAA, α1-, α2A-, α2B-, β1-, and β2-adrenergic, dopamine D1 and D2, and histamine H1 receptors (Kis = >10 µM for all). SB-200646 (20 and 40 mg/kg) reverses mCPP-induced hypophagia and decreases in social interaction time, indicating anxiolytic-like behavior, in rats.

• SKU: CAY30973-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30973-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK