SB-204741, CAS 152239-46-8

Formulation: A solid

Formal Name: N-(1-methyl-1H-indol-5-yl)-N′-(3-methyl-5-isothiazolyl)-urea

Purity: ≥95%

Formula Markup: C14H14N4OS

Formula Weight: 286,4

Shelf life (days): 1460

CAS Number: 152239-46-8

Notes: SB-204741 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2B.{61368} It inhibits 5-HT-induced contraction of isolated rat stomach fundus, a tissue that endogenously expresses high levels of 5-HT2B receptors (pA2 = 7.95). SB-204741 is selective for 5-HT2B receptors over 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2C, 5-HT3, 5-HT4, dopamine D1-3, histamine H1, α1- and α2-adrenergic, and GABAA receptors (Kis = 1-100 µM). In vivo, SB-204741 (1 mg/kg per day) prevents the development of pulmonary arterial hypertension (PAH) and reduces vascular stiffness in a Bmpr2 mutant mouse model of hereditary PAH.{61369} It also reduces blood pressure in DOCA-salt hypertensive rats.{61370}

• SKU: CAY32965-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 32965-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK