SB-328437, CAS 247580-43-4

Formulation: A crystalline solid

Formal Name: N-(1-naphthalenylcarbonyl)-4-nitro-L-phenylalanine, methyl ester

Purity: ≥98%

Formula Markup: C21H18N2O5

Formula Weight: 378,4

Shelf life (days): 1460

CAS Number: 247580-43-4

Notes: SB-328437 is a nonpeptide chemokine (C-C motif) receptor 3 (CCR3) antagonist (IC50 = 4.5 nM in a radioligand binding assay).{32621} It is selective for CCR3 over chemokine (C-X-C motif) receptor 1 (CXCR1), CXCR2, CCR7, complement 3a receptor (C3aR), and C5aR (IC50s = >27, >27, >33, >10, and >10 µM, respectively). SB-328437 (3.3-1,000 nM) inhibits calcium mobilization induced by chemokine (C-C motif) ligand 11 (CCL11), CCL24, and CCL13 in RBL-2H3-CCR3 cells and eosinophils. In vivo, SB-328437 reduces pulmonary Ccr3 mRNA expression, the number of eosinophils and monocytes in bronchoalveolar lavage fluid (BALF), and pulmonary IL-4 and TNF-α levels in a mouse model of asthma.{49498}

• SKU: CAY29677-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 29677-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK