SB-408124, CAS 288150-92-5

Formulation: A crystalline solid

Formal Name: N-(6,8-difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]-urea

Purity: ≥98%

Formula Markup: C19H18F2N4O

Formula Weight: 356,4

Shelf life (days): 1460

CAS Number: 288150-92-5

Notes: SB-408124 is a potent antagonist of orexin 1 receptors (OX1Rs) with a Ki value of 26.9 nM in a calcium mobilization assay using CHO cells that stably express human OX1R.{34091} It is selective for OX1R over OX2R, with Kd values of 21.7 and 1,704 nM, respectively, in a radioligand binding assay. In vivo co-perfusion of SB-408124 with human OX1R in the rat ventral tegmental area inhibits OX1R-induced glutamate and dopamine elevations and reduces cocaine-seeking behavior in rats.{36123}

• SKU: CAY22961-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22961-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK