Formulation: A solid
Formal Name: 5-chloro-2-(ethylsulfonyl)-4-pyrimidinecarboxylic acid 3-methylphenyl ester
Purity: ≥98%
Formula Markup: C14H13ClN2O4S
Formula Weight: 340,8
Shelf life (days): 1460
CAS Number: 882366-16-7
Notes: SBI-115 is an antagonist of G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5.{49821} It inhibits taurolithocholic acid-induced increases in cAMP levels in, and proliferation of, cholangiocytes isolated from patients with autosomal dominant polycystic kidney disease when used at concentrations of 100 and 200 µM. SBI-115 (10 µM) decreases the viability of, and protein levels of GPBAR1 in, PANC-1 pancreatic cancer cells.{49822} In vivo, SBI-115 (80 mg/kg) prevents B. pseudocatenulatum-induced decreases in serum levels of IFN-γ and IL-17A in a mouse model of collagen-induced arthritis.{49823}
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