Formulation: A crystalline solid
Formal Name: 2R,3R-bis[(4-hydroxy-3-methoxyphenyl)methyl]-1,4-butanediol
Purity: ≥98%
Formula Markup: C20H26O6
Formula Weight: 362,4
Shelf life (days): 1460
CAS Number: 29388-59-8
Notes: (–)-Secoisolariciresinol is a lignan that has been found in flaxseed and has diverse biological activities.{52972,52973,52974} It scavenges DPPH (Item No. 14805) radicals (IC50 = 13.7 µg/ml in a cell-free assay).{52972} (–)-Secoisolariciresinol (0.1-100 µM) stimulates IgM production in HB4C5 hybridoma cells.{52973} It induces estrogen receptor-dependent gene expression in a reporter assay, as well as stimulates proliferation of MCF-7 human breast cancer cells, in a concentration-dependent manner. (–)-Secoisolariciresinol (5.8 mg/kg, p.o.) reduces weight gain and serum adiponectin levels in a mouse model of obesity induced by a high-fat diet (HFD).{52974}
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