Formulation: A solid
Formal Name: 4,7-dihydro-N-methyl-5H-thieno[2,3-c]pyran-7-methanamine, monohydrochloride
Purity: ≥98%
Formula Markup: C9H13NOS • HCl
Formula Weight: 219,7
Shelf life (days): 1460
CAS Number: 1310422-41-3
Notes: SEP-363856 is an agonist of trace amine-associated receptor 1 (TAAR1).{66353} It increases intracellular cAMP levels in cells expressing TAAR1 (EC50 = 0.14 µM). It is also an agonist of the serotonin (5-HT) receptor subtypes 5-HT1D and 5-HT1A, decreasing cAMP levels in cells expressing these receptors (EC50s = 0.262 and 2.3 µM, respectively). SEP-363856 is selective for these receptors over the dopamine D2L receptor (EC50s = 10.44 and 8.02 µM in cAMP and arrestin recruitment assays, respectively), as well as α2A- and α2B-adrenergic, and 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT7 receptors (EC50s = 6.7->10 µM in functional assays). It reduces hyperactivity induced by phencyclidine (PCP) in mice when administered at 0.3, 1, and 3 mg/kg and reverses PCP-induced impairments in social interaction in rats. SEP-363856 (3, 10, and 30 mg/kg) increases prepulse inhibition of the acoustic startle response in mice. It also decreases the time spent immobile in the forced swim test in mice, indicating antidepressant-like activity.
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