Formulation: A crystalline solid
Formal Name: ζ-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-benzeneheptanoic acid
Purity: ≥98%
Formula Markup: C22H26O4
Formula Weight: 354,4
Shelf life (days): 1460
CAS Number: 112665-43-7
Notes: Seratrodast is a potent antagonist of the thromboxane A2 (TXA2) receptor (TP), blocking specific binding of U-46619 (Item No. 16450) to guinea pig platelets with an IC50 value of 7.4 nM and platelet aggregation induced by U-44069 (Item No. 16440) with an IC50 value of 350 nM.{26820,26819} It is metabolized, in liver microsomes, by cytochrome P450 (CYP) isoforms 3A and 2C9/10, with a minor contribution from CYP2C8 and CYP2C19.{26816} Seratrodast is commonly used to study the roles of the TP receptor in animal airways and in tissue samples.{26820,26817,26818,26815}