Seratrodast, CAS 112665-43-7

Formulation: A crystalline solid

Formal Name: ζ-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-benzeneheptanoic acid

Purity: ≥98%

Formula Markup: C22H26O4

Formula Weight: 354,4

Shelf life (days): 1460

CAS Number: 112665-43-7

Notes: Seratrodast is a potent antagonist of the thromboxane A2 (TXA2) receptor (TP), blocking specific binding of U-46619 (Item No. 16450) to guinea pig platelets with an IC50 value of 7.4 nM and platelet aggregation induced by U-44069 (Item No. 16440) with an IC50 value of 350 nM.{26820,26819} It is metabolized, in liver microsomes, by cytochrome P450 (CYP) isoforms 3A and 2C9/10, with a minor contribution from CYP2C8 and CYP2C19.{26816} Seratrodast is commonly used to study the roles of the TP receptor in animal airways and in tissue samples.{26820,26817,26818,26815}

• SKU: CAY9002014-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 9002014-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK