Formulation: A neat oil
Formal Name: 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)-propane
Purity: ≥95%
Formula Markup: C4H3F7O
Formula Weight: 200,1
Shelf life (days): 1460
CAS Number: 28523-86-6
Notes: Sevoflurane is a halogenated ether with anesthetic properties.{41455} It enhances the activity of GABAA and glycine receptors and inhibits the activity of nicotinic acetylcholine receptors (nAChRs) and glutamate receptors. Sevoflurane enhances the responses of α2β1 subunit-containing GABAA and α1 subunit-containing glycine receptors at submaximal agonist concentrations in HEK293 cells (EC50s = 0.45 and 0.36 mM, respectively).{41456} Sevoflurane (360 µM) also increases the amplitude of GABAA receptor responses to GABA stimulation for receptors with an α1β2γ2 subunit composition.{41457} It inhibits binding of the high affinity nicotinic agonist epibatidine to nAChRs in mouse brain membranes (IC50 = 0.77 mM).{41458} Formulations containing sevoflurane have been used in the induction and maintenance of general anesthesia.
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