Formulation: A solid
Formal Name: 1-(β-D-glucopyranosyloxy)-1S,4aS,5R,6,7S,7aS-hexahydro-5,7-dihydroxy-7-methyl-cyclopenta[c]pyran-4-carboxylic acid, methyl ester
Purity: ≥98%
Formula Markup: C17H26O11
Formula Weight: 406,4
Shelf life (days): 1460
CAS Number: 64421-28-9
Notes: Shanzhiside methyl ester is an iridoid glycoside that has been found in L. rotata and has anti-inflammatory and antinociceptive activities.{60632,60633} It is a glucagon-like peptide 1 receptor (GLP-1R) agonist.{60632} Shanzhiside methyl ester (10 µM) inhibits the release of myeloperoxidase (MPO) and elastase from isolated rat neutrophils activated by N-Formyl-Met-Leu-Phe (fMLF; Item No. 21495).{60633} It also inhibits LPS-induced increases in the release of IL-8 and leukotriene B4 (LTB4; Item Nos. 20110 / 10007240) from isolated rat neutrophils when used at a concentration of 10 µM. Shanzhiside methyl ester reduces L5/L6 spinal nerve ligation-induced mechanical allodynia in rats (ED50 = 40.4 µg/animal), an effect that can be reversed by the GLP-1R antagonist exendin (9-39).{60632}
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