Formulation: A crystalline solid
Formal Name: 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol, monohydrobromide
Purity: ≥98%
Formula Markup: C18H20ClNO2 • HBr
Formula Weight: 398,7
Shelf life (days): 1460
CAS Number: 67287-95-0
Notes: SKF 83959 is a partial agonist at the dopamine D1-like receptors (Kis = 1.18 and 7.56 nM, respectively, for D1 and D5) that is selective over the D2-like receptors (Kis = 920 and 399 nM, respectively, for D2 and D3).{24103,40094} It is protective against oxidative stress in retinal ganglion cells after hydrogen peroxide-induced injury in vitro.{40095} In a rat methylazoxymethanol acetate (MAM) model of schizophrenia, it had positive effects on hippocampal function, determined using electrophysiology, but impaired spatial learning.{40096} SKF 83959 can also act as an allosteric modulator of the sigma-1 (σ1) receptor by enhancing the binding to and delaying the dissociation of the selective σ1-receptor agonist pentazocine.{40097}
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