Formulation: A solid
Formal Name: N-(4-(1-hydroxy-2-((propan-2-yl-1,1,1,3,3,3-d6)amino)ethyl)phenyl)methanesulfonamide, monohydrochloride
Purity: ≥99% deuterated forms (d1-d6);
Formula Markup: C12H14D6N2O3S • HCl
Formula Weight: 314,9
Shelf life (days): 1460
CAS Number: 1246820-85-8
Notes: Sotalol-d6 is intended for use as an internal standard for the quantification of sotalol (Item No. 16136) by GC- or LC-MS. Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent.{26305,48449} It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM.{45726} Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES).{26305} Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).
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