Spadin (trifluoroacetate salt)

Formulation: A solid

Formal Name: L-tyrosyl-L-alanyl-L-prolyl-L-leucyl-L-prolyl-L-arginyl-L-tryptophyl-L-serylglycyl-L-prolyl-L-isoleucylglycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-L-arginine, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C96H142N26O22 • XCF3COOH

Formula Weight: 2012,3

Shelf life (days): 1460

Notes: Spadin is an inhibitor of the two-pore domain potassium channel K2P2.1/TREK1 (Ki = 10 nM in homogenates from COS-7 cells expressing K2P2.1/TREK1) that corresponds to amino acids 12-28 of human sortilin, also known as the neurotensin-3 receptor (NTS3).{64566} It also binds to sortilin in C13NJ microglial cells (Ki = 8 nM). Spadin inhibits currents induced by arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) in COS-7 cells expressing K2P2.1/TREK1 (IC50 = 70.7 nM). It decreases immobility time in the forced swim test in mice.

• SKU: CAY36762-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36762-5
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe