Formulation: A solution in water
Formal Name: N1-(3-aminopropyl-1,1,2,2,3,3-d6)butane-1,4-diamine
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C7H13D6N3
Formula Weight: 151,3
Shelf life (days): 730
CAS Number: 2514812-10-1
Notes: Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine (Item No. 14918) by GC- or LC-MS. Spermidine is an endogenous polyamine.{58623} It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay.{58623} It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans.{58634} Spermidine (30 mM in the drinking water) reduces demyelination of the optic nerve and disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).{58625} It reduces increases in blood pressure, left ventricular posterior wall thickness, and heart weight in salt-sensitive Dahl rats fed a high-salt diet, a model of hypertension-induced congestive heart failure.{58633} Formulations containing spermidine have been used as dietary supplements.
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