Formulation: A solid
Formal Name: L-asparaginyl-L-tryptophyl-L-threonyl-L-prolyl-L-glutaminyl-L-alanyl-L-methionyl-L-leucyl-L-tyrosyl-L-leucyl-L-lysylglycyl-L-alanyl-L-glutamamide, acetate
Purity: ≥98%
Formula Markup: C74H114N20O19S • XC2H4O2
Formula Weight: 1619,9
Shelf life (days): 1460
Notes: Spexin 1 is an endogenous peptide and agonist of galanin-2 receptor (GAL2) and GAL3.{62835} It selectively activates GAL2 and GAL3 over GAL1 in HEK293 cells expressing the human receptors and Gαqi (EC50s = 0.161, 0.626, and >10 µM, respectively, in reporter assays). Spexin 1 (50 µg/kg) decreases body weight, fat mass, serum triglyceride levels, and blood glucose and insulin levels in a mouse model of high-fat diet-induced hepatic steatosis.{62836} Intracerebroventricular administration of spexin 1 (30 nmol/animal) decreases heart rate and urine flow rate, increases mean arterial pressure (MAP) and urinary sodium excretion, and has antinociceptive activity in the warm water tail withdrawal test in rats.{62837}
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