Formulation: A crystalline solid
Formal Name: (5Z)-7-[(1S,2R,3R,4R)-3-[[2-[(phenylamino)carbonyl]hydrazinyl]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid
Purity: ≥98%
Formula Markup: C21H29N3O4
Formula Weight: 387,5
Shelf life (days): 1460
CAS Number: 98672-91-4
Notes: SQ 29,548 is a highly selective TP receptor antagonist which binds to the human recombinant TP receptor with a Ki of 4.1 nM.{8322} It inhibits the aggregation of washed human platelets induced by U-46619 with an IC50 of 0.06 µM.{6643} It antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and venous smooth muscles with drug/receptor dissociation constants (KB) in the range of 0.5-1.7 nM.{1099} SQ 29,548 also inhibits the contraction of rat vascular smooth muscle induced by 8-iso PGF2α.{955}