Formulation: A solid
Formal Name: 1-(6-chloro-2-pyridinyl)-4-piperidinamine, monohydrochloride
Purity: ≥98%
Formula Markup: C10H14ClN3 • HCl
Formula Weight: 248,2
Shelf life (days): 1460
CAS Number: 77145-61-0
Notes: SR 57227A is an agonist of the serotonin (5-HT) receptor subtype 5-HT3.{57930} It selectively binds 5-HT3 receptors (IC50 = 2.8 nM) over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2, and 5-HT4 receptors (IC50s = >1,000 nM for all). SR 57227A (20 µM) induces contractions in isolated guinea pig ileum, an effect that can be reversed by the 5-HT3 antagonist tropisetron (Item No. 21240). Intrastriatal administration of SR 57227A (1 µg/animal) induces contralateral turning behavior in mice. It reduces immobility time in the forced swim test in rats (ED50 = 7.6 mg/kg), as well as reduces the number of escape failures in a rat model of learned helplessness and the duration of fighting in a mouse model of isolation-induced aggression.{57931}
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