Formulation: A solid
Formal Name: N-[2-(3,4-dihydroxyphenyl)ethyl]-octadecanamide
Purity: ≥95%
Formula Markup: C26H45NO3
Formula Weight: 419,6
Shelf life (days): 1460
CAS Number: 105955-10-0
Notes: Stearda is an endogenous fatty acid amide composed of the catecholamine dopamine (Item Nos. 36532 / 21992) conjugated to the long-chain saturated fatty acid stearic acid (Item No. 10011298).{11037} It is an inhibitor of 5-lipoxygenase (5-LO; IC50 = 16 nM). Stearda is cytotoxic to K562 chronic myeloid leukemia cells, HOS osteosarcoma fibroblasts, and IMR-32 neuroblastoma cells but not MCF-7 breast cancer cells (IC50s = 36.8, 15, 1.5, and >100 µM, respectively).{66639} It potentiates calcium influx induced by the arachidonoyl amino acid and cannabinoid 1 (CB1) receptor agonist N-arachidonoyl dopamine (NADA; Item No. 90057) in HEK293 cells expressing human transient receptor potential vanilloid 6 (TRPV6) when used at concentrations of 1 or 10 µM.{13227} In vivo, stearda (0.1 mg/ml per paw), in combination with NADA, decreases latency to paw withdrawal in the hot plate test in rats.
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