STING Agonist 12L, CAS 2913152-30-2

Formulation: A solid

Formal Name: 2-([3,4'-bipyridazine]-6-carboxamido)-4-ethynyl-5-fluorobenzoic acid

Purity: ≥98%

Formula Markup: C18H10FN5O3

Formula Weight: 363,3

Shelf life (days): 730

CAS Number: 2913152-30-2

Notes: STING agonist 12L is an agonist of stimulator of interferon genes (STING).{51392} It binds to wild-type STING (IC50 = 1.15 µM), as well as the STING R232, AQ, and Q variants (IC50s = 1.06, 0.61, and 1.12 µM, respectively) and induces reporter gene expression in THP-1 and RAW 264.7 cells (EC50s = 0.38 and 12.94 µM, respectively). STING agonist 12L (5 µM) induces IFNB1, CXCL10, and IL6 mRNA expression in THP-1 cells. In vivo, STING agonist 12L (10 mg/kg) increases plasma IFN-β levels and reduces tumor volume and the number of lung metastases in a B16/F10 murine melanoma model.

• SKU: CAY38344-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38344-1
• Package Unit: 1 mg
• Quantity Unit: STK