Formulation: A lyophilized powder
Formal Name: (S)-2-((S)-1-(L-arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C63H98N18O13S • XCF3COOH
Formula Weight: 1347,6
Shelf life (days): 1460
CAS Number: 148470-19-3
Notes: Substance P is tachykinin neuropeptide that selectively binds to neurokinin 1 (NK1) receptors (Kis = 0.14 and 300 nM for NK1 and NK3, respectively) and has diverse biological activities.{40688,40689} It is an endogenous peptide expressed in the central and peripheral nervous systems, including the enteric nervous system and in immune cells.{40689} Substance P is released with other neurotransmitters in the dorsal horn of the spinal cord following noxious peripheral stimulation and induces pain through NK1 receptors.{40690} The NK1 receptor is internalized following substance P binding, and in a rat hindpaw model of inflammation it is internalized in a greater number of spinal cord neurons following a mechanical or non-noxious stimuli, indicating a role for substance P in inflammation and hyperalgesia.{40691} Substance P is also involved in depression, anxiety, seizures, and emesis among other functions.{40689}
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