Formulation: A solid
Formal Name: (3aR,4S,7R,7aS)-rel-hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione
Purity: ≥95%
Formula Markup: C21H29N5O2
Formula Weight: 383,5
Shelf life (days): 1460
CAS Number: 87760-53-0
Notes: Tandospirone is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A.{66707} It selectively binds to 5-HT1A receptors (Ki = 0.027 µM) over 5-HT2, 5-HT1B, 5-HT1C, and 5-HT1D receptors (Kis = 1.3, >100, 2.6, and >100 µM, respectively), as well as α1-adrenergic receptors (α1-ARs), α2-ARs, β-ARs, and dopamine D1 and D2 receptors (Kis = 1.6, 1.9, >100, 1.7, and 41 µM, respectively). Tandospirone (0.1-100 µM) reduces forskolin-induced adenylate cyclase activity in rat hippocampal homogenates. In vivo, tandospirone (10 and 20 mg/kg) reduces immobility time in the forced swim test in mice.{66708} Tandospirone (10 mg/kg) increases food intake and overall survival, as well as decreases body weight loss in a Yoshida hepatoma rat model of cancer cachexia.{66709} Formulations containing tandospirone have been used in the treatment of depression.
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